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Mastra vs AutoGen

MastraAutoGen

Bottom line: Mastra for typeScript and full-stack JavaScript teams; AutoGen for teams already running AutoGen in production.

MastraMastra

The TypeScript framework for building AI agents and workflows.

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AutoGenAutoGen

Microsoft's multi-agent conversation framework (now in maintenance mode).

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Votes00
PricingFreemiumFree
CategoryAgent FrameworksAgent Frameworks
Tags
agentstypescriptopen-sourceworkflowrag
agentsmulti-agentopen-sourcemicrosoftorchestration
Best for
  • TypeScript and full-stack JavaScript teams
  • Startups shipping AI features fast
  • Developers wanting agents without Python
  • Teams already running AutoGen in production
  • Researchers studying multi-agent systems
  • Developers prototyping agent collaboration
Pros
  • TypeScript-native, rare among serious agent frameworks
  • Open source and free to self-host
  • Ergonomic agents, workflows, memory, and evals in one toolkit
  • Strong funding and momentum (22k+ GitHub stars)
  • Fits full-stack and front-end teams
  • Pioneered accessible multi-agent conversation patterns
  • Free and open source
  • Backed by Microsoft Research with strong documentation
  • 0.4 architecture is asynchronous and more observable
  • Works with many model providers
Cons
  • Young project with a still-maturing ecosystem
  • APIs may change as it evolves toward stability
  • Fewer integrations than older Python frameworks
  • TypeScript-only, no Python option
  • Managed cloud pricing not fully transparent
  • In maintenance mode as of 2026, no new feature focus
  • Microsoft steers new projects to the Agent Framework
  • Multiple version lines (0.2 vs 0.4/0.7) cause confusion
  • Multi-agent loops can be hard to control and cost-predict
  • Less enterprise tooling than the successor framework

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